Tolerability of agents intended for contact with human tissues. Soft tissues to implanted or injected substances is important in the assessment of the local Nevertheless unusual types of mesenchymal neoplasms are encountered that do not fitĬareful recording of the nature, intensity and duration of the inflammatory response of the Range of soft tissue neoplasms described in rodents is far less than those characterized in Hence, the basicĬlassification developed for mesenchymal lesions can be used for all species, although the Similar among different laboratory rodent species as well as humans. The pathological features of both spontaneous and induced conditions of soft tissues are INHAND classification of lesions of the skeletal system. Lesions of the synovium are discussed under the Regenerate in the same way as epithelial cells although the exact mechanisms involvedįollowing injury remain uncertain ( 82Mutsaers et al. Mesothelial cellsĪre derived from the mesoderm but express many epithelial characteristics. Non-malignant supporting stroma ( 114Valtieri and Sorrentino 2008).įor convenience, mesothelial lesions are also reviewed in this document. Have a central role in the pathogenesis and progression of neoplasia as part of the Important in the functional repair of damaged tissues. Marrow but also in other sites including adipose tissue and skeletal muscle ( 69Liu et al. These cells are undifferentiated multi-potential cells which reside primarily in the bone This simple concept must now be modified since theĭiscovery of mesenchymal stem cells and their important contribution to tissue homeostasis These areĪccompanied by blood vessels and mobile bone-marrow derived cells such as lymphocytes, Substance and various structural proteins including collagen and elastic fibers. The conventional view of the soft tissues is one of a cellular component comprisingįibroblasts, fat containing cells, specialized skeletal muscle fibers, a matrix of ground Misleading comparisons with particular diseases. Descriptive rather than diagnostic terminology is advisable in order to avoid In these studies microscopic observations should be recorded in a consistent and objective The basic principles for recording microscopic changes in toxicity studies have been Presented here is also available electronically at the goRENI website (Thisĭocument follows a similar approach to these previous publications. These STP publications haveīeen used for this current classification. International Agency for Research on Cancer classification of tumors in mice and rats These were subject toĮxtensive reviews and comments by members of STP and were used as the basis for the WHO. Non-proliferative lesions of the soft tissues of both rats and mice has been previouslyġ992 51Greaves and Seely 1996 48Greaves et al. Standardized nomenclature of proliferative and
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Nomenclature for classifying proliferative and non-proliferative lesions observed in soft The purpose of this publication is to provide a standardized Internationally-accepted nomenclature for proliferative and non-proliferative lesions in The INHAND Project ( International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathologyįrom Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an Increase and enrich international exchanges of information among toxicologists and Scientific research organizations in different countries and provide a common language to Muscle and mesothelium in laboratory animals will decrease confusion among regulatory and Utilized international harmonization of nomenclature for lesions in soft tissues, skeletal Lesions as well as those induced by exposure to test materials. Content includes spontaneous developmental and aging
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Material included histopathology databases from government, academia, and industrial
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The standardized nomenclature of lesions presented in this document isĪlso available electronically on the Internet (). Lesions observed in the soft tissues including skeletal muscle as well as the mesothelium Purpose of this publication is to provide a standardized nomenclature for classifying Nomenclature for proliferative and nonproliferative lesions in laboratory animals. (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted Initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain The INHAND Project (International Harmonization of Nomenclature andĭiagnostic Criteria for Lesions in Rats and Mice) is a joint